VP/VA64

White or yellowish-white powder or flake solid, soluble in water, ethanol or methylene chloride. It is prepared by copolymerization of 1-vinyl-2-pyrrolidone and vinyl acetate in a mass ratio of 3:2. Strong plasticity, and does not affect the pressure of the tablet force change, can give the tablet good hardness, is the best dry adhesive applied to the direct tablet process.

Pharmacopoeia Name: Copovidone
English Abbreviation: VP/VA 64
CAS No.: 25086-89-9

Category: Pharmaceutical Excipients

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PRODUCT DETAILS

Product Description

White or yellowish-white powder or flake solid, soluble in water, ethanol or methylene chloride. It is prepared by copolymerization of 1-vinyl-2-pyrrolidone and vinyl acetate in a mass ratio of 3:2. Strong plasticity, and does not affect the pressure of the tablet force change, can give the tablet good hardness, is the best dry adhesive applied to the direct tablet process.

Quality Index

K Value：	25.2-30.8
Aldehyde(acetaldehyde)：	≤0.05%
N-Vinyl-2-Pyrrolidinone	≤0.001%
Vinyl Acetate：	≤0.001%
α- pyrrolidinone：	≤0.5%
Peroxide(H2O2)：	≤0.04%
Hydrazine：	≤0.0001%
Loss on Drying	≤5.0%
Residue on Ignition	≤0.1%
Heavy Metal:	≤twenty parts per million
Nitrogen Content：	11.5%-12.8%

Main functions

film forming agent, adhesive, humectant, etc.

Application

• Medicine: As an adhesive, it is suitable for the wet and dry granulation process of tablets and the direct pressing process of powders to improve the compressibility of particles; As a coating film forming agent, it is applied to the coating of tablet film. As a pore-causing agent, it is used in odor masking preparations and sustained-release preparations. As a solubilizer, it can be used in solid dispersion process.

• Daily Cosmetics: PVP-VA series plays the role of film forming agent and setting agent, and the higher the proportion of vinyl acetate, the lower the hygroscopic property, it is suitable for mousse, eruption agent and hair fixing solution. When mixed with PVP-K30, the fixed hair effect can be enhanced.

• Other Industries: Can be used for rewet binder, paper adhesive. As a thickening agent and protective colloid for various inks. The water-soluble PVP-VA64 series products are also commonly used as emulsifiers and protective colloids for plant protection agents, and can also be used as adhesives for paints.