Crospovidone XL/XL-10

White or off-white powder, insoluble in water, ethanol or chloroform, odorless or slightly characteristic odor, easy to absorb moisture. It is a highly cross-linked network molecular structure with strong water absorption and expansion ability, and does not form high-viscosity gels.

Pharmacopoeia Name: Crospovidone
English Abbreviation: PVPP
CAS No.: 9003-39-8

Category: Pharmaceutical Excipients

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PRODUCT DETAILS

Product Description

White or off-white powder, insoluble in water, ethanol or chloroform, odorless or slightly characteristic odor, easy to absorb moisture. It is a highly cross-linked network molecular structure with strong water absorption and expansion ability, and does not form high-viscosity gels.

Quality Index

PH (1% w/v suspended aqueous solution)	5.0-8.0
Soluble matter in water	≤50mg（1.0%）
N-ethylene-2-pyrrolidone	≤0.001%
Peroxide(as H2O2）	≤0.04%
Moisture content	≤5.0%
Residue on ignition	≤0.1%
Heavy metals	≤10 parts per million
Arsenic salts	≤0.0002%

Main Functions

Pharmaceutical excipients, disintegrants, fillers, stabilizers, adsorbents, humectants, eta.

Application

• Pharma: As a suspension stabilizer, it reduces the sedimentation of drug particles and increases the redispersion capacity of the settled liquid; As a complexing agent and adsorbent in the preparation, it stabilizes the active ingredients of the drug through complexation and improves the release and bioavailability of the drug; As a super disintegrant in the preparation, it can quickly swell and disintegrate the preparation, effectively improve the dissolution and bioavailability of the drug, and can adapt to the wet granulation and direct tableting process. (Note: Different particle sizes are used in different addition methods, and there are also different effects on drugs.)

• Brewing and beverage: It can be used as a stabilizer and adsorbent for beer, juice, beverages to prolong its storage time and improve the taste without affecting the flavor of the beverage.

• Commodity chemical industry：It can be used as a high-end cosmetic moisturizer. Used in skin care products, it has analgesia and reduces irritation. It has a therapeutic effect on skin inflammation, acne, erythema. Use in toothpaste, it can be anti-inflammatory, detoxifying, analgesic, not only to clean the mouth, but also to treat the gums.

Advantages

• Adopt a low-vacuum self-crosslinking process: Make the polymerization more sufficient, and the product has higher water absorption, expansion volume and expansion rate;

• Adopt self-developed physical-chemical synergistic post-treatment technology: Fully remove trace impurities such as residues and ketones in the product, and the product appearance and odor performance are better, and at the same time, it has higher safety;

• Unique drying technology: It avoids the influence of traditional high-temperature drying on the molecular structure and properties of the product, and reduces the risk of water absorption and swelling performance caused by aging and curling of the product.